id: Pfam:PF14818
pfam_id: PF14818
name: SOGA 1/2-like, coiled-coil
short_name: SOGA1-2-like_CC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14818
counters:
  proteins: 2945
  matches: 2946
  proteomes: 745
  taxa: 2252
  structures: 0
  alphafold_models: 735
  domain_architectures: 19
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027882
description: This entry represents a coiled-coil region found in microtubule cross-linking factors 1 and
  2 (also known as SOGA1/2), which are members of the SOGA (suppressor of glucose by autophagy) family
  and in the uncharacterised human protein KIAA0408. SOGA1 regulates autophagy by playing a role in the
  reduction of glucose production in an adiponectin- and insulin-dependent manner [[cite:PUB00067397]].
  SOGA1/2 are required for faithful chromosome segregation during mitosis [[cite:PUB00153172]]. These
  proteins contain long coiled-coils that dimerize and holds two N-terminal domains that bind to microtubules
  [[cite:PUB00153172]]. This region is found in association with [pfam:PF11365].