id: Pfam:PF14892
pfam_id: PF14892
name: Piercer of microtubule wall 1/2
short_name: PIRC1_2
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14892
counters:
  proteins: 1504
  matches: 1504
  proteomes: 1009
  taxa: 3488
  structures: 17
  alphafold_models: 1319
  domain_architectures: 22
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR026507
description: This family of proteins is found in eukaryotes and includes Piercer of microtubule wall 1/2
  proteins (PIRC1/2). In mice PIRC1 expression is induced by p53 may play a role in DNA damage response
  and has been shown to function at the initial step of left-right asymmetry specification of the visceral
  organs [[cite:PUB00111186]]. PIRC1/2 are microtubule inner proteins involved in the attachment of outer
  dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme [[cite:PUB00100771]].