id: Pfam:PF14908
pfam_id: PF14908
name: CCDC81 eukaryotic HU domain 1
short_name: HU-CCDC81_euk_1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14908
counters:
  proteins: 1262
  matches: 1264
  proteomes: 801
  taxa: 2643
  structures: 9
  alphafold_models: 1098
  domain_architectures: 38
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR028034
description: This is the first of two HU domains found in the CCDC81-like proteins. CCDC81 has been experimentally
  linked to the centrosome; eukaryotic CCDC81 HU domains are predicted to function in protein-protein
  interactions in centrosome organization and potentially contribute to cargo-binding in conjunction with
  Dynein-VII. A striking lineage-specific expansion of the domain is observed in birds, where the HU domains
  could function in recognition of non-self molecules [[cite:PUB00091007]].