id: Pfam:PF14970
pfam_id: PF14970
name: Tubulin epsilon and delta complex protein 1
short_name: TEDC1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14970
counters:
  proteins: 1191
  matches: 1245
  proteomes: 831
  taxa: 2779
  structures: 0
  alphafold_models: 1019
  domain_architectures: 14
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027996
description: This family represents the tubulin epsilon and delta complex protein 1 (TEDC1). This complex
  is required for centriole maintenance and it is a component of several ciliary structures. It acts as
  a positive regulator of hedgehog signalling, which play key roles in embryonic development and in cancers
  [[cite:PUB00094182]]. Additionally, this protein may play a role in counteracting perturbation of actin
  filaments, such as after treatment with the actin depolymerising microbial metabolite Chivosazole F
  [[cite:PUB00094181]].