id: Pfam:PF15061
pfam_id: PF15061
name: MITRAC7/Phoenixin family
short_name: MITRAC7_Phoenixin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15061
counters:
  proteins: 807
  matches: 807
  proteomes: 648
  taxa: 2471
  structures: 0
  alphafold_models: 717
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027917
description: This entry represents the Small Integral Membrane Protein 20/Phoenixin family, which contains
  proteins with dual functions. The full-length protein (SMIM20/MITRAC7) is a mitochondrial inner membrane
  protein that acts as a component of the MITRAC (mitochondrial translation regulation assembly intermediate
  of cytochrome c oxidase) complex, regulating cytochrome c oxidase assembly. It functions as a chaperone-like
  assembly factor required to stabilize newly synthesized MT-CO1/COX1 and prevent its premature turnover.
  The C-terminal region of this protein is also processed to produce bioactive peptides known as phoenixin-14
  and phoenixin-20, which were first identified through a bioinformatic approach. These secreted peptides
  are involved in multiple physiological functions. They act as ligands for the G protein-coupled receptor
  GPR173. Phoenixin peptides regulate gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus
  and pituitary, augmenting luteinizing hormone release. They delay the appearance of estrus when reduced
  in vivo and modulate GnRH receptor expression. Additionally, phoenixin peptides regulate vasopressin
  secretion by hypothalamic neurons and have roles in memory retention, anxiety reduction, food intake
  regulation, granulosa cell proliferation, heart function, and islet cell proliferation.