id: Pfam:PF15093
pfam_id: PF15093
name: Sperm-associated microtubule inner protein 4
short_name: SPMIP4-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15093
counters:
  proteins: 575
  matches: 610
  proteomes: 397
  taxa: 1493
  structures: 3
  alphafold_models: 487
  domain_architectures: 8
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027886
description: This family (previously DUF4555) includes the homologs of human sperm-associated microtubule
  inner protein 4 (SPMIP4) that is found predominantly in testis [[cite:PUB00151495]]. SPMIP4 is a microtubule
  inner protein (MIP) part of the axonemal dynein-decorated doublet microtubules (DMTs). Members of this
  family adopt rather extended conformation and contain a single or multiple Mn motifs. Each Mn motif
  consists of a 5- to 6-residue helix flanked by a Tyr/Phe residue on one end and by a Ser/Thr on the
  other that binds the shoulder of the alpha-tubulin S9/S10 loop [[cite:PUB00151502]]. Members of this
  family are likely to stabilise the microtubule structure in the sperm flagella [[cite:PUB00151496]].