id: Pfam:PF15133
pfam_id: PF15133
name: TLR adaptor interacting with SLC15A4 on the lysosome
short_name: TASL
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15133
counters:
  proteins: 812
  matches: 817
  proteomes: 469
  taxa: 1580
  structures: 1
  alphafold_models: 704
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027869
description: In humans, TASL (TLR adaptor interacting with SLC15A4 on the lysosome) is encoded by CXorf21
  that is associated with systemic lupus erythematosus [[cite:PUB00093601]]. It is an immune adaptor that
  is required for recruitment and activation of IRF5 by TLR7, TLR8 and TLR9, in mechanistic analogy to
  IRF3 and its three adaptors STING, MAVS and TRIF. TASL interacts with the endolysosomal transporter
  SLC15A4 forming the SLC15A4-TASL complex, which is required for endolysosomal TLR signalling. TASL contains
  a pLxIS motif that is important for its function [[cite:PUB00095082]].