id: Pfam:PF15158
pfam_id: PF15158
name: Cation channel sperm-associated auxiliary subunit TMEM249
short_name: TMEM249
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15158
counters:
  proteins: 281
  matches: 289
  proteomes: 243
  taxa: 946
  structures: 3
  alphafold_models: 232
  domain_architectures: 13
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027861
description: This family of proteins is found in eukaryotes and includes Cation channel sperm-associated
  auxiliary subunit TMEM249 from human (also known as C8orfK29). It is an auxiliary component of the CatSper
  complex, a complex involved in sperm cell hyperactivation [[cite:PUB00100197]]. TMEM249 contributes
  to the assembly of the CatSpermasome.