id: Pfam:PF15162
pfam_id: PF15162
name: Protein SPO16 homolog
short_name: SCRE
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15162
counters:
  proteins: 556
  matches: 558
  proteomes: 477
  taxa: 1717
  structures: 0
  alphafold_models: 485
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027857
description: This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex
  reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key
  role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting
  in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ
  cells [1. It promotes homologous recombination and crossing-over in meiotic prophase I via its association
  with SHOC1 [[cite:PUB00096701]]. It is also required for the localization of TEX11 and MSH4 to recombination
  intermediates [[cite:PUB00096701]].