id: Pfam:PF15223
pfam_id: PF15223
name: Elongin BC and Polycomb repressive complex 2-associated protein
short_name: EPOP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15223
counters:
  proteins: 888
  matches: 905
  proteomes: 644
  taxa: 2016
  structures: 1
  alphafold_models: 764
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027971
description: This family of proteins is found in eukaryotes. Family members are approximately 835 amino
  acids in length and include the polycomb repressive complex 2-associated factor EPOP (Elongin BC and
  Polycomb Repressive Complex 2 (PRC2) Associated Protein, also termed C17orf96, esPRC2p48, E130012A19Rik),
  a scaffold protein expressed in the inner cell mass of the mouse blastocyst serving as a bridging partner
  between the PRC2/EED-EZH2 complex and the elongin BC complex, and fine-tuning the transcriptional status
  of Polycomb group (PcG) target genes in embryonic stem cells. Both EPOP and Elongin BC are required
  to maintain low levels of expression at PRC2 genomic targets [[cite:PUB00083907]]. EPOP interacts with
  the H2B deubiquitinase USP7 to modulate transcriptional processes in mESCs similar to MYC [[cite:PUB00083908]].
  Functional studies found that the C-terminal region of EPOP directly interacts with PRC2 and that this
  region associates with the VEFS-box of the PRC2 core member SUZ12. Thus, suggesting that EPOP may directly
  affect PRC2 chromatin binding by altering the functionality of Suz12. This region is proposed to have
  evolved in early vertebrates and is also present in the paralog SKIDA1 (C10orf140) another novel PRC2-interacting
  protein, supporting the idea that proteins possessing this sequence are PRC2 regulators in the entire
  vertebrate branch [[cite:PUB00111127]]. The family is found in association with [pfam:PF02437].