id: Pfam:PF15232
pfam_id: PF15232
name: Domain of unknown function (DUF4585)
short_name: DUF4585
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15232
counters:
  proteins: 1772
  matches: 1772
  proteomes: 702
  taxa: 2139
  structures: 0
  alphafold_models: 455
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027838
description: The function of this protein domain family is yet to be characterised. It is putatively thought
  to lie in the C-terminal domain of the DNA nucleotide repair protein, Xeroderma pigmentosa complementation
  group A (XPA). The function of XPA is to bind to DNA and repair any mismatched base pairs. This domain
  family is often found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved
  DPE sequence motif. In humans, this protein is encoded for in the chromosomal position, Chromosome 5
  open reading frame 65. Mutations in the gene lead to myelodysplastic syndromes, where there is inefficient
  stem cell production in the bone marrow. This suggests that the protein may have a role in forming blood
  cells [[cite:PUB00067380]].