id: Pfam:PF15251
pfam_id: PF15251
name: Telomere attrition and p53 response 1 protein-like
short_name: TAPR1-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15251
counters:
  proteins: 2553
  matches: 2580
  proteomes: 1830
  taxa: 5222
  structures: 0
  alphafold_models: 2173
  domain_architectures: 20
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR029196
description: This entry represents the Telomere attrition and p53 response 1 protein (TAPR1) from eukaryotes,
  including TAPR1 from human (also known as C16orf72/HAPSTR1), which is a multistress-responsive protein
  that functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and
  probably also DNA damage. It may attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1
  which also promotes TAPR1's degradation [[cite:PUB00100199],[cite:PUB00101217]]. This family also includes
  uncharacterised proteins from fungi, such as YJR056C from yeast.