id: Pfam:PF15363
pfam_id: PF15363
name: BTB/POZ domain-containing protein 8, C-terminal
short_name: BTBD8_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15363
counters:
  proteins: 1304
  matches: 1304
  proteomes: 654
  taxa: 2031
  structures: 0
  alphafold_models: 302
  domain_architectures: 14
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027907
description: This domain is found at the C terminus of BTB/POZ domain-containing protein 8 (BTBD8, also
  known as AP2-interacting clathrin-endocytosis protein). BTBD8 is involved in clathrin-mediated endocytosis
  at the synapse and plays a role in neuronal development and in synaptic vesicle recycling in mature
  neurons, a process required for normal synaptic transmission [[cite:PUB00090548]]. There is a conserved
  ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally
  important.