id: Pfam:PF15373
pfam_id: PF15373
name: Stabilizer of axonemal microtubules 5
short_name: SAXO5-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15373
counters:
  proteins: 425
  matches: 447
  proteomes: 338
  taxa: 1187
  structures: 0
  alphafold_models: 349
  domain_architectures: 9
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR028001
description: This family (previously DUF4601) represents the homologues of Stabilizer of axonemal microtubules
  5 (SAXO5, also known as C19orf45, TEX45). SAXO5 is a filamentous SAXO protein that binds along protofilament
  A04 with 96-nm periodicity [[cite:PUB00151496]]. A typical feature of SAXO proteins is the presence
  of Mn motif which forms a 5- to 6-residue helix flanked by a Tyr/Phe residue on one end and by a Ser/Thr
  on the other that binds the shoulder of the alpha-tubulin S9/S10 loop [[cite:PUB00151502]]. SAXO5 contains
  11 Mn motifs and therefore has 96-nm periodicity, matching the external periodicity of the axoneme [[cite:PUB00151496]].