id: Pfam:PF15390
pfam_id: PF15390
name: WD repeat and coiled-coil-containing protein family
short_name: WDCP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15390
counters:
  proteins: 1391
  matches: 1501
  proteomes: 809
  taxa: 2555
  structures: 0
  alphafold_models: 1266
  domain_architectures: 10
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR028041
description: This family includes WD repeat and coiled-coil-containing protein (WDCP, previously known
  as C2orf44), which is found in eukaryotes and consists of around 721 amino acids. The N-terminal contains
  two WD (tryptophan-aspartic acid) repeats (WD1 and WD2). WD repeats may be involved in a range of biological
  functions including apoptosis, transcriptional regulation and signal transduction. The C-terminal contains
  a proline-rich sequence (PPRLPQR), and is predicted to have leucine-rich coiled coil region (CC) [[cite:PUB00080737]].
  WDCP was identified in a proteomic screen to find signalling components that interact with Hck (hematopoietic
  cell kinase), a non-receptor tyrosine kinase. WDCP was shown to bind tightly and specifically to the
  SH3 domain of Hck in U937 human monocytic cells. WDCP was also shown to exist as an oligomer when expressed
  in mammalian cells. While the function of WDCP is unknown, it has been identified in a gene fusion event
  with anaplastic lymphoma kinase (ALK) in colorectal cancer patients [[cite:PUB00080737]].