id: Pfam:PF15395
pfam_id: PF15395
name: Retroelement silencing factor 1 C-terminal region
short_name: RESF1_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15395
counters:
  proteins: 453
  matches: 514
  proteomes: 284
  taxa: 954
  structures: 0
  alphafold_models: 20
  domain_architectures: 8
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027866
description: This entry represents the C-terminal region of approximately 1000 residues found in retroelement
  silencing factor 1 (RESF1) proteins in vertebrates. The full-length RESF1 protein interacts with the
  histone methyltransferase SETDB1 and is required for the recruitment of SETDB1 to endogenous retroviruses
  (ERVs), contributing to ERV silencing in embryonic stem cells [[cite:PUB00092441]]. The specific function
  of this C-terminal region remains to be determined.