id: Pfam:PF15710
pfam_id: PF15710
name: Break repair meiotic recombinase recruitment factor 1
short_name: Brme1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15710
counters:
  proteins: 393
  matches: 519
  proteomes: 232
  taxa: 865
  structures: 2
  alphafold_models: 330
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR031441
description: Brme1 (also known as Meiok21) is a component of meiotic recombination bridges involved in
  meiotic double-strand break repair [[cite:PUB00095580],[cite:PUB00095581]]. The C-terminal domain of
  Brme1 physically interacts with the N-terminal domain of HSF2BP [[cite:PUB00095580]]. BRME1 facilitates
  the loading of RAD51 and DMC1 recombinases onto DSBs (DNA double-strand breaks) through interaction
  with MEILB2/HSF2BP and replacing ssDNA binding proteins [[cite:PUB00095581]]. Brme1 is highly expressed
  in mice testes and fetal ovaries. Knockout of Brme1 results in male mice infertility [[cite:PUB00095580]].