id: Pfam:PF15749
pfam_id: PF15749
name: MRN-interacting protein
short_name: MRNIP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15749
counters:
  proteins: 1583
  matches: 1591
  proteomes: 1219
  taxa: 4007
  structures: 0
  alphafold_models: 1370
  domain_architectures: 27
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR049472
description: This family is found in eukaryotes. Family members include MRN complex-interacting protein
  (MRNIP), which plays a role in preventing the accumulation of damaged DNA in cells. It associates with
  the MRE11-RAD50-NBS1 (MRN) damage-sensing complex and is rapidly recruited to sites of DNA damage. Phosphorylation
  of a serine promotes nuclear localization of MRNIP [[cite:PUB00083234]].