id: Pfam:PF15771
pfam_id: PF15771
name: Interactor of HORMAD1 protein 1
short_name: IHO1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15771
counters:
  proteins: 713
  matches: 748
  proteomes: 630
  taxa: 1947
  structures: 0
  alphafold_models: 652
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR031529
description: Interactor of HORMAD1 protein 1 (IHO1, previously known as coiled-coil domain-containing
  protein 36 or DUF4700) is required for DNA double-strand breaks (DSBs) formation in unsynapsed regions
  during meiotic recombination. It is thought to function, in collaboration with SPO11-auxiliary proteins
  MEI4 and REC114, through the formation of DSB-promoting recombinosomes on chromatin at the onset of
  meiosis [[cite:PUB00083216]].