id: Pfam:PF15831
pfam_id: PF15831
name: Small integral membrane protein 5/18/22
short_name: SMIM5_18_22
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15831
counters:
  proteins: 1626
  matches: 1626
  proteomes: 714
  taxa: 2179
  structures: 0
  alphafold_models: 1524
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR031671
description: This entry represents a small family of single-pass membrane proteins described as small
  integral membrane proteins, including SMIM5/18/22 which have been described as variants of the Cancer-Associated
  Small Integral Membrane Open reading frame 1 (CASIMO1), a small open reading frame (sORF)-encode protein.
  CASIMO1 controls cell proliferation and interacts with squalene epoxidase (SQLE) modulating lipid droplet
  formation. CASIMO1 RNA is overexpressed predominantly in hormone receptor-positive breast tumors. Loss
  of CASIMO1 disturbs the organisation of the actin cytoskeleton, leads to inhibitions of cell motility,
  and stalls the cell cycle in the G0/G1 phase [[cite:PUB00102005]].