id: Pfam:PF15837
pfam_id: PF15837
name: Transmembrane protein 262
short_name: TMEM262
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15837
counters:
  proteins: 207
  matches: 208
  proteomes: 174
  taxa: 622
  structures: 3
  alphafold_models: 174
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR040431
description: This entry represents transmembrane protein 262, also known as cation channel sperm-associated
  auxiliary subunit eta or CATSPERH. TMEM262 is an auxiliary component of the CatSper complex, which is
  involved in sperm cell hyperactivation. The protein is a component of the CatSpermasome, a multi-subunit
  complex composed of core pore-forming members and auxiliary members that form a cation channel essential
  for sperm motility. TMEM262 interacts with CATSPERB and helps stabilise the complex. The protein contains
  three transmembrane helices and is localised to the flagellar membrane of sperm cells. TMEM262 is found
  in mammals and is specifically expressed in testis tissue. The protein is essential for male fertility
  through its role in sperm hyperactivation.