id: Pfam:PF15854
pfam_id: PF15854
name: G-protein coupled receptor ligand 15
short_name: GPR15L
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15854
counters:
  proteins: 121
  matches: 122
  proteomes: 114
  taxa: 422
  structures: 1
  alphafold_models: 106
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR031713
description: GPR15 is an orphan G protein-coupled receptor (GPCR) that is found in lymphocytes. It functions
  as a co-receptor of simian immunodeficiency virus and HIV-2 and plays a role in the trafficking of T
  cells to the lamina propria in the colon and to the skin [[cite:PUB00088053]]. An activating ligand
  named GPR15L is shown to bind GPR15 and attract GPR15-expressing T cells including lymphocytes in colon-draining
  lymph nodes and thymic precursors of dermal epithelial T cell. This 9kDa CC-motif containing cationic
  polypeptide has been previously described as the 57 amino acid antimicrobial peptide AP-57, and as a
  Sushi Containing Domain-2 (SUSD2)-binding factor (CSBF), capable of inhibiting the growth of intestinal
  epithelial cancer cell lines. The chemokine is expressed by epithelial cells in gastrointestinal and
  genitourinary mucosae and in the skin [[cite:PUB00088054]]. In humans GPR15L, is encoded by the gene
  C10ORF99 and has some features similar to the CC family of chemokines [[cite:PUB00088053]]. However,
  it lacks significant homology to classic CC and CXC chemokines, yet shares many features with them,
  including a cationic domain predicted to comprise two disulfide bonds and a highly conserved GPCR-activating
  terminal peptide. Furthermore, the activating peptides of CC chemokines are typically located at the
  N-terminus, while that of GPR15L is C-terminal, a feature that it shares with some other GPCR ligands
  like chemerin and apela [[cite:PUB00088054]].