id: Pfam:PF15878
pfam_id: PF15878
name: Protein Frey
short_name: Frey
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF15878
counters:
  proteins: 176
  matches: 183
  proteomes: 158
  taxa: 568
  structures: 0
  alphafold_models: 154
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR031748
description: This family represents Frey proteins, which are key regulators for male fertility expressed
  transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane
  and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly
  of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome
  [[cite:PUB00101875],[cite:PUB00101874]]. Frey interacts with SPPL2C, which inhibits its intramembrane
  protease activity directly accessing the catalytic centre of an I-CLiP [[cite:PUB00101875]].