id: Pfam:PF16016
pfam_id: PF16016
name: VAD1 Analog of StAR-related lipid transfer domain
short_name: VASt
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16016
counters:
  proteins: 12938
  matches: 14430
  proteomes: 3299
  taxa: 8680
  structures: 12
  alphafold_models: 9903
  domain_architectures: 194
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR031968
description: 'The VASt (VAD1 Analog of StAR-related lipid transfer) domain is conserved across eukaryotes
  and is structurally related to Bet v1-like domains, including START lipid-binding domains. The 190-amino
  acid VASt domain is predominantly associated with lipid binding domains such as GRAM [pfam:PF02893],
  C2 and PH domains. The VASt domain is likely to have a function in binding large hydrophobic ligands
  and may be specific for sterol [[cite:PUB00084279],[cite:PUB00084280]]. The predicted structure of the
  VASt domain is a two-layer sandwich alpha beta fold, also called ''helix grip fold'', containing three
  alpha helices (alpha1 to 3), six beta-sheets (beta1 to 6) and two loops (omega1 and 2) numbered from
  N to C terminus [[cite:PUB00084279]]. Some proteins known to contain a VASt domain are : Plant vascular
  associated death1 (VAD1), a regulator of programmed cell death (PCD) harboring a GRAM putative lipid-binding
  domain. Yeast SNF1 Interacting Protein 3 (SIP3), may be involved in sterol transfer between intracellular
  membranes. Yeast Suicide Protein 1 (YSP1), a mitochondrial protein specifically required for the mitochondrial
  thread-grain transition, de-energization, and the cell death. May be involved in sterol transfer between
  intracellular membranes. Yeast Suicide Protein 2 (YSP2), a mitochondrial membrane protein involved in
  mitochondrial fragmentation and may be involved in sterol transfer between intracellular membranes.It
  is also found in human GramD1a-c.'