id: Pfam:PF16090
pfam_id: PF16090
name: Protein capicua homolog-like domain
short_name: Cic
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16090
counters:
  proteins: 1545
  matches: 1549
  proteomes: 802
  taxa: 2815
  structures: 0
  alphafold_models: 277
  domain_architectures: 28
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR032147
description: This domain is found in protein capicua homolog (Cic) and similar animal proteins. Cic is
  a transcriptional repressor which plays a role in the development of the central nervous system (CNS).
  In concert with ATXN1 and ATXN1L, it is involved in brain development [[cite:PUB00148730],[cite:PUB00053281],[cite:PUB00148732]].
  This domain is predicted to adopt a mainly beta-configuration.