id: Pfam:PF16297
pfam_id: PF16297
name: RTL1/3-8/LDOC, capsid-like domain
short_name: RTL1-8_LDOC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16297
counters:
  proteins: 7561
  matches: 7573
  proteomes: 514
  taxa: 1766
  structures: 0
  alphafold_models: 4801
  domain_architectures: 405
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR032549
description: This entry represents a domain found in eukaryotic Gag or capsid-like retrotranspon-related
  proteins, including LDOC1, and RTL1/3-8 from animals. LDOC1 is a MZF-1-interacting protein, inhibits
  NF-kappaB activation and relates with cancer and some other diseases [[cite:PUB00070719],[cite:PUB00076517],[cite:PUB00076518],[cite:PUB00076519]].
  LDOC1 is a small protein and this entry covers almost its full length. In RTL proteins, it represents
  the N-terminal capsid-like domain. RTL1 plays an essential role in capillaries endothelial cells for
  the maintenance of feto-maternal interface and for development of the placenta [[cite:PUB00091629]].
  RTL3 plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal
  [[cite:PUB00163386]].