id: Pfam:PF16347
pfam_id: PF16347
name: N-sulphoglucosamine sulphohydrolase, C-terminal
short_name: SGSH_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16347
counters:
  proteins: 3391
  matches: 3396
  proteomes: 1958
  taxa: 4533
  structures: 11
  alphafold_models: 2414
  domain_architectures: 46
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR032506
description: This domain is found at the C-terminal end of sulfatases and alkaline phosphatases from bacteria,
  eukaryotes and archaea, including N-sulphoglucosamine sulphohydrolase from humans (SGSH) and Bifunctional
  sulfatase/alpha-L-rhamnosidase from Formosa agariphila (P36_S1_25). It shows a four-stranded antiparallel
  beta-sheet, with four surrounding alpha-helices, followed by a C-terminal extension consisting of a
  small two-stranded antiparallel beta-sheet [[cite:PUB00093668],[cite:PUB00100986]].