id: Pfam:PF16472
pfam_id: PF16472
name: LRP1, beta-propeller domain
short_name: LRP1-like_beta_prop
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF16472
counters:
  proteins: 1489
  matches: 1662
  proteomes: 869
  taxa: 2200
  structures: 1
  alphafold_models: 807
  domain_architectures: 367
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR032485
description: This is a beta-propeller domain found in Prolow-density lipoprotein receptor-related protein
  1 (LRP1) from human, an endocytic receptor involved in endocytosis and in phagocytosis of apoptotic
  cells [[cite:PUB00151931],[cite:PUB00151932]]. LRP1 is involved in cellular lipid homeostasis and in
  the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as
  the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. It
  acts as an LRPAP1 alpha-2-macroglobulin receptor [[cite:PUB00151934],[cite:PUB00151933]].