id: Pfam:PF17198
pfam_id: PF17198
name: Spirocyclase AveC-like
short_name: AveC_like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17198
counters:
  proteins: 854
  matches: 854
  proteomes: 334
  taxa: 536
  structures: 0
  alphafold_models: 589
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR033459
description: AveC catalyzes the stereospecific spiroketalization of a dihydroxy-ketone polyketide intermediate
  in the biosynthetic pathway of Avermectin, a potent antiparasitic agent. Additionally, it has a unique
  dehydration activity that serves to determine the regiospecific saturation pattern for spiroketal diversity
  [[cite:PUB00081205]]. MeiC, the counterpart in the biosynthesis of AVE-like meilingmycin, also has spirocyclase
  activity, but lacks the dehydratase activity.