id: Pfam:PF17229
pfam_id: PF17229
name: Serine/threonine-protein kinase SMG1 N-terminal
short_name: SMG1_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17229
counters:
  proteins: 1092
  matches: 1093
  proteomes: 638
  taxa: 2006
  structures: 2
  alphafold_models: 117
  domain_architectures: 18
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR035175
description: This entry represents the N-terminal disordered region of SMG1, which is a member of the
  phosphoinositide 3 kinase-like kinase (PIKK) family. SMG1 associates with components of the mRNA surveillance
  complex and is involved in the regulation of nonsense-mediated mRNA decay [[cite:PUB00085231]]. It also
  plays an important role in genotoxic stress responses to DNA damage [[cite:PUB00085233]].