id: Pfam:PF17495
pfam_id: PF17495
name: Vpr-like OrfA
short_name: OrfA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17495
counters:
  proteins: 14
  matches: 14
  proteomes: 0
  taxa: 13
  structures: 0
  alphafold_models: 1
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR035276
description: Family members include OrfA protein, a multifunctional accessory protein found in Feline
  immunodeficiency virus (FIV), a lentivirus that causes AIDS in domestic cats [[cite:PUB00085284]]. Multiple
  potential functions have been ascribed to OrfA, including transactivation of viral protein expression
  [[cite:PUB00085285]], effects on virion formation and infectivity [[cite:PUB00085286]], host cell cycle
  arrest [[cite:PUB00085291]] and downregulation of cell surface expression of the primary FIV receptor,
  CD134 [[cite:PUB00085287]].