id: Pfam:PF17653
pfam_id: PF17653
name: Family of unknown function (DUF5522)
short_name: DUF5522
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17653
counters:
  proteins: 2412
  matches: 2412
  proteomes: 2151
  taxa: 4314
  structures: 0
  alphafold_models: 1609
  domain_architectures: 40
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR040807
description: This is a family of unknown function. Family members are found in Bacteria and Eukaryotes.
  In algae, this family is found on the N-terminal of diphthamide synthase family [pfam:PF01902] and is
  predicted to be a membrane transporter belonging to The ATP-binding Cassette (ABC) family [[cite:PUB00091274]].
  In nematoda, it is found on the N-terminal side of ribosomal protein family L14 [pfam:PF00238]. It is
  also found on the N-terminal of Cob(I)alamin adenosyltransferase [pfam:PF01923] in other eukaryotes.
  Family members found in homo sapiens such as [swissprot:Q5VUE5], have been shown to be highly expressed
  in 15 high-grade neuroendocrine tumor cell lines and YAP1-positive small-cell lung cancer cell lines
  [[cite:PUB00091275]] as well as being up-regulated in two human Multiple Myloma cell lines in response
  to selective nuclear export inhibitor KPT-276 [[cite:PUB00091276]]. The HMM profile of this family reveals
  4 highly conserved cysteines.