id: Pfam:PF17659
pfam_id: PF17659
name: RPA-related protein RADX N-terminal domain
short_name: RADX
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17659
counters:
  proteins: 614
  matches: 615
  proteomes: 402
  taxa: 1399
  structures: 2
  alphafold_models: 534
  domain_architectures: 23
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR061920
description: This entry represents the N-terminal domain of a family of proteins that includes RPA-related
  protein RADX from animals, the human member is also known as CXorf57. High-throughput sequencing used
  to identify genes driving tumorigenesis in Avian leukosis virus (ALV)-induced B-cell lymphomas, showed
  CXorf57 as the 10th most frequently targeted common integration site by ALV. ALV induces B-cell lymphoma
  and other neoplasms in chickens by integrating within or near cancer genes and perturbing their expression
  [[cite:PUB00138338]]. RADX is a replication factor A protein-like (RPA-like), single-stranded DNA binding
  protein recruited to replication forks to maintain genome stability [[cite:PUB00091321]]. It also modulates
  stalled fork protection by antagonising RAD51 [[cite:PUB00091322]]. These proteins consist of four tandem
  OB fold domains.