id: Pfam:PF17703
pfam_id: PF17703
name: piRNA-mediated silencing protein C19orf84
short_name: C19orf84
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17703
counters:
  proteins: 132
  matches: 132
  proteomes: 122
  taxa: 402
  structures: 0
  alphafold_models: 110
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR040606
description: This entry, previously known as DUF5549, represents the piRNA-mediated silencing protein
  C19orf84 and related proteins found in mammals. C19orf84 is essential for orchestrating piRNA-directed
  DNA methylation [[cite:PUB00158929]]. C19orf84 interacts with SPOCD1 and mediates the in vivo association
  of SPOCD1 with the de novo methylation machinery. DNMT3C, the DNA methyltransferase responsible for
  transposon methylation, associates with SPOCD1 and C19ORF84 [[cite:PUB00158929]].