id: Pfam:PF17720
pfam_id: PF17720
name: RNA ligase 1
short_name: RLIG1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17720
counters:
  proteins: 882
  matches: 923
  proteomes: 614
  taxa: 2034
  structures: 2
  alphafold_models: 721
  domain_architectures: 7
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR041211
description: This entry includes RNA ligase 1 from animals (RLIG1), which functions as an RNA ligase in
  vitro [[cite:PUB00151146]]. This protein catalyses ATP-dependent RNA ligation via a three-step mechanism,
  involving tandem auto- and RNA AMPylation. It exhibits selectivity for single-stranded RNA substrates.
  RLIG1 may play a role in maintaining RNA integrity under stress conditions, such as in response to reactive
  oxygen species (ROS) [[cite:PUB00151146]].