id: Pfam:PF17825
pfam_id: PF17825
name: SHOC1 ATPase domain
short_name: SHOC1_ATPase
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF17825
counters:
  proteins: 793
  matches: 818
  proteomes: 575
  taxa: 2030
  structures: 0
  alphafold_models: 301
  domain_architectures: 29
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR063559
description: This domain is found in the human Protein shortage in chiasmata 1 ortholog (SHOC1) and related
  proteins from chordate. SHOC1 is an integral to the formation of crossover recombination intermediates
  during mammalian meiosis [[cite:PUB00090399]]. SHOC1 preferentially binds branched DNA molecules but
  apparently lacks in vitro endonuclease activity [[cite:PUB00090399]]. The core of SHOC1 resembles the
  DNA repair endonuclease XPF. This domain has significant similarity to P-loop AAA ATPase domains. This
  aligns with the SHOC1 ATPase activity, which is stimulated by the presence of single-stranded DNA [[cite:PUB00090399]].