id: Pfam:PF18057
pfam_id: PF18057
name: Domain of unknown function (DUF5594)
short_name: DUF5594
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF18057
counters:
  proteins: 200
  matches: 200
  proteomes: 169
  taxa: 192
  structures: 1
  alphafold_models: 139
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR040953
description: This domain was first discovered in BPSL1050, a highly immunoreactive protein found in Burkholderia
  pseudomallei. The domain's structure consists of three helical regions which pack onto an antiparallel
  beta sheet, formed by four strands. The beta sheet is solvent exposed on one side and packs tightly
  against the three helices on the other side, generating a network of hydrophobic and aromatic interactions
  that contribute to tight packing of the protein. Is is thought that the small loop L1, the main loop
  L2, and part of helix alpha-3 extending until Leu120 are the three main immunogenic sequences [[cite:PUB00091370]].