id: Pfam:PF18300
pfam_id: PF18300
name: Domain of unknown function (DUF5604)
short_name: DUF5604
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF18300
counters:
  proteins: 1278
  matches: 1296
  proteomes: 604
  taxa: 1964
  structures: 24
  alphafold_models: 821
  domain_architectures: 50
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR040880
description: This domain is often found in the N-terminal region of proteins carrying the SET domain ([pfam:PF00856]),
  such as the SETDB1 protein present in Homo sapiens. SETDB1 is a histone methyltransferase that suppresses
  gene expression and modulates heterochromatin formation through H3K9me2/3 [[cite:PUB00091314]].