id: Pfam:PF19151
pfam_id: PF19151
name: Sublancin
short_name: Sublancin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19151
counters:
  proteins: 5
  matches: 5
  proteomes: 5
  taxa: 28
  structures: 1
  alphafold_models: 3
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR026479
description: This family represents sublancin, a small bacteriocin active against Gram-positive bacteria.
  This family appears to be restricted to Bacilli. Sublancin was thought to be a lantibiotic but was later
  shown to be an S-linked glycopeptide [[cite:PUB00060499],[cite:PUB00094614]]. Glycosylation is essential
  for its antimicrobial activity. Sublancin is biosynthesised as a precursor peptide bearing an N-terminal
  leader peptide, and a C-terminal core peptide that is converted into the mature peptide [[cite:PUB00060499]].
  Sublancin comprises two alpha helices and a well-defined inter-helical loop [[cite:PUB00094615]]. Sublancin
  inhibits B.cereus spore outgrowth, after the germination stage, approximately 1000-fold better than
  it inhibits exponential growth of the same cells and inhibits B.subtilis strain ATCC6633 and B. megaterium
  strain 14581 [[cite:PUB00094614]].