id: Pfam:PF19179
pfam_id: PF19179
name: E3 ubiquitin-protein ligase TTC3/DZIP3 domain
short_name: TTC3_DZIP3_dom
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19179
counters:
  proteins: 1379
  matches: 1380
  proteomes: 560
  taxa: 2123
  structures: 0
  alphafold_models: 430
  domain_architectures: 87
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR043866
description: This domain is found in E3 ubiquitin-protein ligases TTC3 and DZIP3 and its function is unknown.
  TTC3 mediates ubiquitination and degradation of phosphorylated Akt, apparently its preferable target
  [[cite:PUB00094613]]. DZIP3 is also able to bind RNA through a Lys-rich region which enhances is ubiquitination
  activity. It is suggested that RNA-binding proteins or ribonucleoprotein particles might be physiological
  targets for this enzyme, which could be important during viral infections, especially for those replicating
  through RNA intermediates [[cite:PUB00077706]]. This domain is also found in uncharacterised proteins
  found in viruses.