id: Pfam:PF19213
pfam_id: PF19213
name: Coronavirus replicase NSP6
short_name: CoV_NSP6
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19213
counters:
  proteins: 1387
  matches: 1387
  proteomes: 59
  taxa: 328
  structures: 0
  alphafold_models: 81
  domain_architectures: 81
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR043610
description: This entry represents proteins found in Coronaviruses and includes the Non-structural Protein
  6 (NSP6). Coronaviruses encode large replicase polyproteins which are proteolytically processed by viral
  proteases to generate mature Nonstructural Proteins (NSPs) [[cite:PUB00094417]]. NSP6 is a membrane
  protein containing 6 transmembrane domains with a large C-terminal tail [[cite:PUB00094417]]. NSP6 from
  the avian coronavirus, infectious bronchitis virus (IBV) and the mouse hepatitis virus (MHV) have been
  shown to localise to the ER and to generate autophagosomes [[cite:PUB00094416]]. Coronavirus NSP6 proteins
  have also been shown to limit autophagosome expansion. This may favour coronavirus infection by reducing
  the ability of autophagosomes to deliver viral components to lysosomes for degradation [[cite:PUB00094416]].
  NSP6 from IBV, MHV and severe acute respiratory syndrome coronavirus (SARS-CoV) have also been found
  to activate autophagy [[cite:PUB00094416],[cite:PUB00094418]].