id: Pfam:PF19296
pfam_id: PF19296
name: RelA/SpoT AH domain
short_name: RelA_AH
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19296
counters:
  proteins: 18698
  matches: 18698
  proteomes: 15805
  taxa: 21983
  structures: 9
  alphafold_models: 11911
  domain_architectures: 39
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR045600
description: This entry represents the alpha helical (AH) domain found in RelA/SpoT proteins, adjacent
  to the ACT domain [[cite:PUB00095792],[cite:PUB00098872]]. The AH domain interacts with A/R tRNA and
  links the very C-terminal subdomains with TGS domain. RelA/SpoT-homologue proteins (RHS) mediate the
  stringent response in bacteria which enables its metabolic adaptation under stress conditions. These
  enzymes synthesise the second messenger (p)ppGpp, which is a regulatory metabolite of the stringent
  response characterised by growth arrest and the modulation of gene expression in response to various
  nutritional stresses [[cite:PUB00095792],[cite:PUB00098872],[cite:PUB00059269]].