id: Pfam:PF19375
pfam_id: PF19375
name: DurN substrate-assisted peptide maturase
short_name: DurN
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19375
counters:
  proteins: 42
  matches: 42
  proteomes: 38
  taxa: 81
  structures: 3
  alphafold_models: 23
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR045994
description: This entry represents a member of a biosynthetic gene cluster (BGC) involved in duramycin
  biosynthesis, a ribosomally synthesized and post-translationally modified peptide (RiPP) produced by
  various actinomycetes and marine symbionts. Duramycin binds phosphatidylethanolamine (PE), a major structural
  phospholipid in mammalian and microbial cell membranes which contains 19 amino acids and 5 post-translational
  modifications (PTMs). This entry represents DurN, an enzyme that forms (2S,9S)-Lal one of the two last
  PTMs. DurN catalyses stereospecific and diastereoselective Lal formation in an unusual substrate-assisted
  mechanism in which the active site residues that make the reaction proceed come from the substrate itself,
  manoeuvred into position by DurN [[cite:PUB00152101]].