id: Pfam:PF19543
pfam_id: PF19543
name: Glycoside hydrolase 123, N-terminal domain
short_name: GH123_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19543
counters:
  proteins: 306
  matches: 306
  proteomes: 271
  taxa: 442
  structures: 0
  alphafold_models: 189
  domain_architectures: 8
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR045711
description: This domain is found at the N-terminal end of protein members of the glycoside hydrolase
  family 123, including N-acetylgalactosaminidase from Clostridium perfringens. This enzyme removes specific
  terminal N-D-acetylgalactosamine from glycosphingolipids. This domain folds into a twisted beta-sandwich
  that consists of two 5-stranded beta-sheets, two small beta-strands and four small alpha-helices [[cite:PUB00100654]].