id: Pfam:PF19557
pfam_id: PF19557
name: BrxC/PglY, N-terminal domain
short_name: BrxC-PglY_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19557
counters:
  proteins: 1880
  matches: 1899
  proteomes: 1736
  taxa: 3488
  structures: 3
  alphafold_models: 1075
  domain_architectures: 34
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR045725
description: This entry (ex DUF6079) represents the P-loop domain at the N-terminal in Probable ATP-binding
  protein BrxC and ATPase pglY. BrxC is a core protein of a type 1 BREX system, which provides immunity
  against bacteriophage. The ATPase PglY is part of a type 2 BREX system, which provides immunity against
  bacteriophage infections [[cite:PUB00093365],[cite:PUB00161155],[cite:PUB00151239],[cite:PUB00105105]].
  PglY hydrolyses ATP but not other nucleotides, and its activity is inhibited by the non-hydrolysable
  ATP analogue 5-adenylyl beta,gamma-imidodiphosphate.