id: Pfam:PF19647
pfam_id: PF19647
name: 7(1) septoil knot domain
short_name: Septknot
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19647
counters:
  proteins: 615
  matches: 616
  proteomes: 583
  taxa: 1076
  structures: 0
  alphafold_models: 395
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR046148
description: This entry represents a small protein domain with a 7(1) septoil knot topology, one of the
  most complex protein knots known. The structured core consists of a beta-barrel with six beta-strands
  and two short alpha-helices. The domain contains a conserved SFPD tetrapeptide motif in the loops between
  beta-strands, resulting in a pseudo fivefold symmetry with conserved phenylalanine side chains pointing
  outward. The domain is exceptionally stable against chemical denaturation and shows high mechanical
  resistance. The domain was first predicted by AlphaFold2 and experimentally confirmed by X-ray crystallography
  and solution NMR.