id: Pfam:PF19705
pfam_id: PF19705
name: PolF haem-oxygenase-like diiron oxidases
short_name: PolF
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19705
counters:
  proteins: 31
  matches: 31
  proteomes: 29
  taxa: 62
  structures: 11
  alphafold_models: 14
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR045776
description: This entry represents PolF haem-oxygenase-like diiron oxidase which converts the desaturated
  l-isoleucine to polyoximic acid via an intramolecular C-N cyclization [[cite:PUB00164341]]. PolF exhibits
  dual functionality, orchestrating the sequential desaturation and cyclization with l-isoleucine as the
  initial substrate [[cite:PUB00164341]]. PolF folds into a seven-helix bundle, with three core helices
  coordinating the iron cofactor. Members of this family contain a highly conserved H-X3-E-X2-H sequence
  motif that completes the coordination of the diiron cofactors. A member belongs to a biosynthetic gene
  cluster (BGC). This BGC (BGC0000877) includes a member from the polyoxin A biosynthetic gene cluster
  from Streptomyces cacaoi subsp. asoensis [[cite:PUB00098985],[cite:PUB00098986]].