id: Pfam:PF19877
pfam_id: PF19877
name: Cell division protein PerM
short_name: PerM
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF19877
counters:
  proteins: 3622
  matches: 3640
  proteomes: 3589
  taxa: 4293
  structures: 0
  alphafold_models: 2046
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR045931
description: PerM is an integral membrane protein containing 8-10 transmembrane helices that is highly
  conserved amongst mycobacteria and actinobacteria but absent from other bacterial lineages. The protein
  functions as an essential component of the mycobacterial divisome complex, directly interacting with
  FtsB through conserved hydrophobic residues. PerM localises to division septa where it modulates cell
  wall synthesis, with activity critically dependent on magnesium availability. Disruption results in
  magnesium-dependent growth defects, cell elongation, hypersensitivity to beta-lactam antibiotics, and
  severe attenuation during chronic infections. The protein appears to integrate environmental stress
  signals, enabling mycobacteria to regulate cell division in response to host-induced stress during persistent
  infection.