id: Pfam:PF20131
pfam_id: PF20131
name: ABC-three component (ABC-3C) system Middle Component 3
short_name: MC3
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20131
counters:
  proteins: 673
  matches: 673
  proteomes: 650
  taxa: 1443
  structures: 7
  alphafold_models: 386
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR045390
description: Middle Components (MCs) of the ABC-3C biological conflict systems occupy the central position
  between the catalytic effector and ABC ATPases of the systems. MCs are defined by distinctive patterns
  of conserved charged residues. As some MCs are HTH domains, they are predicted to function akin to kleisins
  as DNA-binding partners for the ABC ATPases, assisting in recognition and responding to invasive elements
  such as DNA viruses [[cite:PUB00101219]].