id: Pfam:PF20137
pfam_id: PF20137
name: Bacterial ubiquitination-like system serine protease (BubE)
short_name: BubE
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF20137
counters:
  proteins: 801
  matches: 801
  proteomes: 743
  taxa: 1575
  structures: 0
  alphafold_models: 450
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR045384
description: This family of proteins is functionally uncharacterised. This family This entry represents
  a novel family of serine proteases (BubE) that function in bacterial ubiquitination-like (Bub) pathways.
  BubE proteins contain a conserved serine-histidine catalytic dyad that can cleave both peptide and isopeptide
  bonds. The proteins also contain a conserved C4 zinc finger motif formed by four cysteine residues.
  BubE appears to negatively regulate Bub activity by cleaving ubiquitin-like protein-target conjugates.
  The proteins often contain hydrophobic N- or C-terminal extensions that may mediate association with
  membranes. BubE proteins are found in both Type I and Type II Bub operons, which encode components of
  bacterial protein conjugation systems that function through unusual oxyester intermediates.